Assay Detail
ADMET
CHEMBL4426201
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Agonist activity at human S1P3 receptor expressed in HEK293T cell co-expressing G-alpha15-BLA measured after 45 mins by [35S]GTP-gammaS binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 5.35 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4553789 | — | — | 1 | 6.05 |
| CHEMBL4469843 | — | — | 1 | 5.96 |
| CHEMBL4457691 | — | — | 1 | 5.92 |
| CHEMBL4553546 | — | — | 1 | 5.89 |
| CHEMBL4529165 | — | — | 1 | 5.75 |
| CHEMBL4587424 | — | — | 1 | 5.70 |
| CHEMBL4473672 | — | — | 1 | 5.68 |
| CHEMBL4452807 | — | — | 1 | 5.68 |
| CHEMBL4569675 | — | — | 1 | 5.60 |
| CHEMBL4474984 | — | — | 1 | 5.46 |
| CHEMBL4458762 | — | — | 1 | 5.42 |
| CHEMBL4541678 | — | — | 1 | 5.35 |
| CHEMBL4522539 | — | — | 1 | 5.32 |
| CHEMBL4458575 | — | — | 1 | 5.28 |
| CHEMBL4574665 | — | — | 1 | 5.25 |
| CHEMBL4520384 | — | — | 1 | 5.13 |
| CHEMBL4448752 | — | — | 1 | 5.03 |
| CHEMBL4474880 | — | — | 1 | 5.00 |
| CHEMBL4545842 | — | — | 1 | 4.92 |
| CHEMBL4521128 | — | — | 1 | 4.92 |
| CHEMBL4461520 | — | — | 1 | 4.85 |
| CHEMBL4476492 | — | — | 1 | 4.85 |
| CHEMBL4553920 | — | — | 1 | 4.69 |
| CHEMBL4473311 | — | — | 1 | 4.68 |
| CHEMBL4437944 | — | — | 1 | - |
| CHEMBL4464631 | — | — | 1 | - |
| CHEMBL4440968 | — | — | 1 | - |
| CHEMBL4475594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4553789 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4469843 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4457691 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4553546 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4529165 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4587424 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4473672 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4452807 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4569675 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4474984 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4458762 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4541678 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4522539 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4458575 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4574665 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4520384 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4448752 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4474880 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4545842 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4521128 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4461520 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4476492 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4553920 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4473311 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4437944 | — | EC50 | > | 31000.0 | nM | - |
| CHEMBL4464631 | — | EC50 | > | 31300.0 | nM | - |
| CHEMBL4440968 | — | EC50 | - | — | - | |
| CHEMBL4475594 | — | EC50 | - | — | - |