Assay Detail
Binding
CHEMBL4426210
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Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458575 | — | — | 1 | 9.30 |
| CHEMBL4448752 | — | — | 1 | 9.04 |
| CHEMBL4521128 | — | — | 1 | - |
| CHEMBL4541678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458575 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4448752 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4521128 | — | EC50 | - | — | - | |
| CHEMBL4541678 | — | EC50 | - | — | - |