Assay Detail
Binding
CHEMBL4426219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.12 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458575 | — | — | 1 | 9.28 |
| CHEMBL4448752 | — | — | 1 | 8.96 |
| CHEMBL4521128 | — | — | 1 | - |
| CHEMBL4541678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458575 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4448752 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4521128 | — | EC50 | - | — | - | |
| CHEMBL4541678 | — | EC50 | - | — | - |