Assay Detail
Functional
CHEMBL4426287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction in blood lymphocytes in po dosed Lewis rat measured after 24 hrs
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| EC50 | 2 | 7.72 | 7.72 |
| ED50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448752 | — | — | 3 | 7.72 |
| CHEMBL4458575 | — | — | 3 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448752 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4458575 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4448752 | — | Inhibition | - | % | - | |
| CHEMBL4448752 | — | ED50 | = | 0.6 | mg.kg-1 | - |
| CHEMBL4458575 | — | Inhibition | - | % | - | |
| CHEMBL4458575 | — | ED50 | = | 0.1 | mg.kg-1 | - |