Assay Detail
Binding
CHEMBL4426324
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Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.69 | 8.46 |
| Ki | 2 | 7.02 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435789 | — | — | 1 | 8.46 |
| CHEMBL367444 | — | — | 1 | 8.40 |
| CHEMBL4559129 | — | — | 1 | 7.60 |
| CHEMBL4465332 | — | — | 1 | 7.54 |
| CHEMBL4448273 | — | — | 1 | 7.38 |
| CHEMBL4455360 | — | — | 1 | 7.20 |
| CHEMBL4467748 | — | — | 1 | 7.09 |
| CHEMBL4519822 | — | — | 1 | 7.05 |
| CHEMBL4549357 | — | — | 1 | 7.00 |
| CHEMBL4542394 | — | — | 1 | 6.92 |
| CHEMBL4553625 | — | — | 1 | 6.92 |
| CHEMBL330425 | — | — | 1 | 6.74 |
| CHEMBL1111 | AMBRISENTAN | 4.0 | 1 | 6.71 |
| CHEMBL4565926 | — | — | 1 | 6.69 |
| CHEMBL4521348 | — | — | 1 | 6.68 |
| CHEMBL4540866 | — | — | 1 | 6.54 |
| CHEMBL4568468 | — | — | 1 | 6.54 |
| CHEMBL4528516 | — | — | 1 | 6.51 |
| CHEMBL4444355 | — | — | 1 | 6.50 |
| CHEMBL4463633 | — | — | 1 | 6.48 |
| CHEMBL23261 | DARUSENTAN | 3.0 | 1 | 6.43 |
| CHEMBL2103873 | MACITENTAN | 4.0 | 1 | 6.41 |
| CHEMBL4536769 | — | — | 1 | 6.29 |
| CHEMBL4574034 | — | — | 1 | 6.27 |
| CHEMBL4566095 | — | — | 1 | 6.26 |
| CHEMBL4573806 | — | — | 1 | 6.25 |
| CHEMBL4572734 | — | — | 1 | 6.25 |
| CHEMBL4573273 | — | — | 1 | 6.25 |
| CHEMBL4458005 | — | — | 1 | 6.21 |
| CHEMBL4436531 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435789 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL367444 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4559129 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4465332 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4448273 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4455360 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4467748 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4519822 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4549357 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4542394 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4553625 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL330425 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL1111 | AMBRISENTAN | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4565926 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4521348 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4540866 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4568468 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4528516 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4444355 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL4463633 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL23261 | DARUSENTAN | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL2103873 | MACITENTAN | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL4536769 | — | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL4574034 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL4566095 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL4572734 | — | IC50 | = | 569.0 | nM | 6.25 |
| CHEMBL4573273 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL4573806 | — | IC50 | = | 569.0 | nM | 6.25 |
| CHEMBL4458005 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4436531 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL2165326 | APROCITENTAN | IC50 | = | 987.0 | nM | 6.01 |
| CHEMBL4570529 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL293012 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4449731 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1628688 | ZIBOTENTAN | IC50 | > | 100.0 | nM | - |