Compound Detail
CHEMBL367444
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COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1
Basic Information
| ChEMBL ID | CHEMBL367444 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AEDJOIBTFWFFLB-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
659.8
MW (Da)
5.28
ALogP
11
HBA
2
HBD
158.7
PSA (Ų)
0.16
QED
3
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.4
Kd 2 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin receptor type B CHEMBL1785 | IC50 | 8.4 | 8.4 | 4.0 | 2 |
| Endothelin receptor type B CHEMBL4631 | Kd | 8.04 | 8.04 | 9.1 | 1 |
| Endothelin-1 receptor CHEMBL252 | IC50 | 7.66 | 7.66 | 22.0 | 2 |
| Endothelin-1 receptor CHEMBL4566 | Kd | 6.92 | 6.92 | 120.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin receptor type B | IC50 | = | 4.0 | nM | 8.4 | Inhibitory concentration required against [125I]ET1 binding to membranes of CHO ... | 12617928 |
| Endothelin receptor type B | IC50 | = | 4.0 | nM | 8.4 | Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membra... | 27321813 |
| Endothelin receptor type B | Kd | = | 9.12 | nM | 8.04 | In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction ... | 12617928 |
| Endothelin-1 receptor | IC50 | = | 22.0 | nM | 7.66 | Inhibitory concentration required against [125I]ET1 binding to membranes of CHO ... | 12617928 |
| Endothelin-1 receptor | IC50 | = | 22.0 | nM | 7.66 | Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membra... | 27321813 |
| Endothelin-1 receptor | Kd | = | 120.23 | nM | 6.92 | In vitro inhibitory potency for preventing ET-1 induced constriction of rat aort... | 12617928 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12617928 | 10.1016/s0960-894x(02)01083-1 | Endothelin-1 receptor | 2 |
| 12617928 | 10.1016/s0960-894x(02)01083-1 | Endothelin receptor type B | 2 |
| 27321813 | 10.1016/j.bmcl.2016.06.014 | Endothelin-1 receptor | 1 |
| 27321813 | 10.1016/j.bmcl.2016.06.014 | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine