Assay Detail
Binding
CHEMBL682967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bis-sulfonamides as endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.48 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172297 | — | — | 1 | 7.85 |
| CHEMBL367958 | — | — | 1 | 7.72 |
| CHEMBL367444 | — | — | 1 | 7.66 |
| CHEMBL177802 | — | — | 1 | 7.35 |
| CHEMBL368617 | — | — | 1 | 7.32 |
| CHEMBL172071 | — | — | 1 | 7.30 |
| CHEMBL368738 | — | — | 1 | 7.29 |
| CHEMBL172030 | — | — | 1 | 7.19 |
| CHEMBL367443 | — | — | 1 | 7.11 |
| CHEMBL171950 | — | — | 1 | 7.10 |
| CHEMBL177538 | — | — | 1 | 7.09 |
| CHEMBL276949 | — | — | 1 | 7.07 |
| CHEMBL368107 | — | — | 1 | 6.94 |
| CHEMBL176749 | — | — | 1 | 6.92 |
| CHEMBL369676 | — | — | 1 | 6.85 |
| CHEMBL174413 | — | — | 1 | 6.73 |
| CHEMBL176997 | — | — | 1 | 6.58 |
| CHEMBL172029 | — | — | 1 | 6.31 |
| CHEMBL368528 | — | — | 1 | 6.24 |
| CHEMBL172759 | — | — | 1 | 6.23 |
| CHEMBL367275 | — | — | 1 | 6.14 |
| CHEMBL175268 | — | — | 1 | 5.98 |
| CHEMBL174781 | — | — | 1 | 5.88 |
| CHEMBL277275 | — | — | 1 | 5.88 |
| CHEMBL367274 | — | — | 1 | 5.86 |
| CHEMBL366872 | — | — | 1 | 5.80 |
| CHEMBL174547 | — | — | 1 | 5.73 |
| CHEMBL366628 | — | — | 1 | 5.66 |
| CHEMBL368945 | — | — | 1 | 5.66 |
| CHEMBL366627 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172297 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL367958 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL367444 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL177802 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL368617 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL172071 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL368738 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL172030 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL367443 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL171950 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL177538 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL276949 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL368107 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL176749 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL369676 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL174413 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL176997 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL172029 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL368528 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL172759 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL367275 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL175268 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL174781 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL277275 | — | IC50 | = | 1317.0 | nM | 5.88 |
| CHEMBL367274 | — | IC50 | = | 1385.0 | nM | 5.86 |
| CHEMBL366872 | — | IC50 | = | 1591.0 | nM | 5.80 |
| CHEMBL174547 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL366628 | — | IC50 | = | 2193.0 | nM | 5.66 |
| CHEMBL368945 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL366627 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL367017 | — | IC50 | = | 2838.0 | nM | 5.55 |
| CHEMBL176418 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL173201 | — | IC50 | = | 5115.0 | nM | 5.29 |
| CHEMBL172441 | — | IC50 | = | 8390.0 | nM | 5.08 |