Endothelin-1 receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P26684. Use UniProt P26684 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P26684 as the stable identity anchor, then attach disease evidence before program review.
Endothelin-1 receptor
Review this target as Endothelin-1 receptor, mapped to UniProt P26684. Sequence length is 426 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endothelin-1 receptor as ChEMBL target CHEMBL4566, mapped to UniProt P26684. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Endothelin-1 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P26684 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin-1 receptor |
| UniProt Accession | P26684 |
| Component Type | Protein |
| Sequence Length | 426 aa |
Endothelin-1 receptor
Review this target as Endothelin-1 receptor, mapped to UniProt P26684. Sequence length is 426 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL112624 | 10.82 | IC50 | 0.015 | Preclinical |
| CHEMBL4538570 | 10.59 | IC50 | 0.026 | Preclinical |
| CHEMBL298725 | 10.49 | IC50 | 0.032 | Preclinical |
| CHEMBL9194 | 10.47 | Ki | 0.034 | Clinical |
| CHEMBL1627023 | 10.47 | IC50 | 0.034 | Preclinical |
| CHEMBL305576 | 10.47 | Ki | 0.034 | Preclinical |
| CHEMBL437472 | 10.47 | Ki | 0.034 | Clinical |
| CHEMBL112531 | 10.41 | IC50 | 0.039 | Preclinical |
| CHEMBL369489 | 10.41 | IC50 | 0.039 | Preclinical |
| CHEMBL323464 | 10.4 | IC50 | 0.04 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 21 | 487 | 7.1 |
| single protein format | 15 | 25 | 7.8 |
| tissue-based format | 10 | 251 | 7.2 |
| assay format | 7 | 77 | 6.7 |
| cell membrane format | 6 | 52 | 6.4 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 12 | 49 | 7.2 |
| organism-based format | 5 | 0 | — |
| cell-based format | 4 | 4 | 9.2 |
| tissue-based format | 3 | 2 | 8.6 |