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Evidence Snapshot

Endothelin-1 receptor

CHEMBL4566 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4566
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Endothelin-1 receptor as ChEMBL target CHEMBL4566, mapped to UniProt P26684. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Endothelin-1 receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL4566
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P26684
Endothelin-1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Endothelin-1 receptor matters

As of 2026-09-14

Endothelin-1 receptor is reviewed as Endothelin-1 receptor (UniProt P26684); the current evidence base includes 8 approved drugs, 1030 compounds, and 84 assays, with lead potency reaching pChEMBL 10.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 8 approved drugs, 1030 compounds, and 84 assays for this target. The dominant activity type is IC50. CHEMBL112624 is the current potency anchor at pChEMBL 10.8.

Use CHEMBL112624 as the tractability anchor when discussing potency (pChEMBL 10.8).

Activity source · ChEMBL 36 via Core Engine
8 approved pChEMBL 10.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Endothelin-1 receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P26684, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1030
Total Compounds
84
Total Assays
8
Approved Drugs
IC50: 868.0, KI: 94.0, EC50: 1.0, KD: 81.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL112624
 10.8 IC50 —
No preferred name
CHEMBL4538570
 10.6 IC50 —
No preferred name
CHEMBL298725
 10.5 IC50 —
No preferred name
CHEMBL1627023
 10.5 IC50 —
No preferred name
CHEMBL305576
 10.5 Ki —

Approved Drugs

Structure Compound First Approval
SITAXENTAN
CHEMBL282724
 2006
BOSENTAN
CHEMBL957
 2001
SULFISOXAZOLE
CHEMBL453
 1971
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:41Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4566