Assay Detail
Functional
CHEMBL673746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Trachea |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bis-sulfonamides as endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 7.02 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367444 | — | — | 1 | 8.04 |
| CHEMBL172297 | — | — | 1 | 7.95 |
| CHEMBL176997 | — | — | 1 | 7.48 |
| CHEMBL173201 | — | — | 1 | 7.46 |
| CHEMBL277275 | — | — | 1 | 7.41 |
| CHEMBL367443 | — | — | 1 | 7.31 |
| CHEMBL367274 | — | — | 1 | 7.30 |
| CHEMBL177538 | — | — | 1 | 7.16 |
| CHEMBL172030 | — | — | 1 | 7.15 |
| CHEMBL368107 | — | — | 1 | 6.97 |
| CHEMBL369676 | — | — | 1 | 6.62 |
| CHEMBL172071 | — | — | 1 | 6.57 |
| CHEMBL177802 | — | — | 1 | 6.57 |
| CHEMBL171950 | — | — | 1 | 6.44 |
| CHEMBL367958 | — | — | 1 | 6.36 |
| CHEMBL368738 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367444 | — | Kd | = | 9.12 | nM | 8.04 |
| CHEMBL172297 | — | Kd | = | 11.22 | nM | 7.95 |
| CHEMBL176997 | — | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL173201 | — | Kd | = | 34.67 | nM | 7.46 |
| CHEMBL277275 | — | Kd | = | 38.9 | nM | 7.41 |
| CHEMBL367443 | — | Kd | = | 48.98 | nM | 7.31 |
| CHEMBL367274 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL177538 | — | Kd | = | 69.18 | nM | 7.16 |
| CHEMBL172030 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL368107 | — | Kd | = | 107.15 | nM | 6.97 |
| CHEMBL369676 | — | Kd | = | 239.88 | nM | 6.62 |
| CHEMBL172071 | — | Kd | = | 269.15 | nM | 6.57 |
| CHEMBL177802 | — | Kd | = | 269.15 | nM | 6.57 |
| CHEMBL171950 | — | Kd | = | 363.08 | nM | 6.44 |
| CHEMBL367958 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL368738 | — | Kd | = | 2630.27 | nM | 5.58 |