Assay Detail
Binding
CHEMBL670655
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Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETB receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Bis-sulfonamides as endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172297 | — | — | 1 | 8.70 |
| CHEMBL276949 | — | — | 1 | 8.40 |
| CHEMBL173201 | — | — | 1 | 8.40 |
| CHEMBL367444 | — | — | 1 | 8.40 |
| CHEMBL277275 | — | — | 1 | 8.15 |
| CHEMBL367274 | — | — | 1 | 8.05 |
| CHEMBL177538 | — | — | 1 | 7.82 |
| CHEMBL172030 | — | — | 1 | 7.80 |
| CHEMBL367443 | — | — | 1 | 7.72 |
| CHEMBL176997 | — | — | 1 | 7.62 |
| CHEMBL368107 | — | — | 1 | 7.62 |
| CHEMBL368617 | — | — | 1 | 7.48 |
| CHEMBL175268 | — | — | 1 | 7.09 |
| CHEMBL171950 | — | — | 1 | 7.08 |
| CHEMBL172759 | — | — | 1 | 7.00 |
| CHEMBL366872 | — | — | 1 | 7.00 |
| CHEMBL369676 | — | — | 1 | 6.99 |
| CHEMBL177802 | — | — | 1 | 6.99 |
| CHEMBL367958 | — | — | 1 | 6.91 |
| CHEMBL176418 | — | — | 1 | 6.52 |
| CHEMBL176749 | — | — | 1 | 6.49 |
| CHEMBL366627 | — | — | 1 | 6.46 |
| CHEMBL172071 | — | — | 1 | 6.40 |
| CHEMBL172441 | — | — | 1 | 6.38 |
| CHEMBL367275 | — | — | 1 | 6.35 |
| CHEMBL172029 | — | — | 1 | 6.06 |
| CHEMBL368738 | — | — | 1 | 6.03 |
| CHEMBL366628 | — | — | 1 | 5.81 |
| CHEMBL368945 | — | — | 1 | 5.68 |
| CHEMBL367017 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172297 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL276949 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL367444 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL173201 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL277275 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL367274 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL177538 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL172030 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL367443 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL176997 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL368107 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL368617 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL175268 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL171950 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL366872 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL172759 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL177802 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL369676 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL367958 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL176418 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL176749 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL366627 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL172071 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL172441 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL367275 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL172029 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL368738 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL366628 | — | IC50 | = | 1537.0 | nM | 5.81 |
| CHEMBL368945 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL367017 | — | IC50 | = | 3676.0 | nM | 5.43 |
| CHEMBL174781 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL174413 | — | IC50 | = | 5402.0 | nM | 5.27 |
| CHEMBL368528 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL174547 | — | IC50 | = | 8240.0 | nM | 5.08 |