Assay Detail
Binding
CHEMBL4426334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence of LaCl3 by patch clamp assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 5 (CHEMBL1250411) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential Treatment for Neuropsychiatry Disorders with TRPC5 Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.01 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451083 | — | — | 1 | 8.28 |
| CHEMBL4562137 | — | — | 1 | 8.08 |
| CHEMBL4466158 | — | — | 1 | 8.05 |
| CHEMBL4464289 | — | — | 1 | 7.63 |
| CHEMBL4525688 | — | — | 1 | - |
| CHEMBL4459054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451083 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4562137 | — | IC50 | = | 8.37 | nM | 8.08 |
| CHEMBL4466158 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4464289 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL4525688 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4459054 | — | IC50 | < | 1.0 | nM | - |