Assay Detail
ADMET
CHEMBL4427401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C19 (unknown origin) preincubated for 10 mins followed by addition of MFC as substrate measured after 30 mins in presence of NADP by fluorescence analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469414 | LUVIXASERTIB | 2.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469414 | LUVIXASERTIB | IC50 | = | 8000.0 | nM | 5.10 |