Assay Detail
Functional
CHEMBL4427455
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Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition under aerobic conditions after 5 days by dual read-out fluorescence assay
23
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 17 | - | - |
| IC50 | 6 | 5.11 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4534306 | — | — | 2 | 6.01 |
| CHEMBL4551610 | — | — | 2 | 5.18 |
| CHEMBL4539172 | — | — | 2 | 5.13 |
| CHEMBL4539586 | — | — | 2 | 5.08 |
| CHEMBL4582915 | — | — | 2 | 4.64 |
| CHEMBL4546338 | — | — | 2 | 4.62 |
| CHEMBL4474060 | — | — | 1 | - |
| CHEMBL4453865 | — | — | 1 | - |
| CHEMBL4473148 | — | — | 1 | - |
| CHEMBL4457962 | — | — | 1 | - |
| CHEMBL4593096 | — | — | 1 | - |
| CHEMBL4587484 | — | — | 1 | - |
| CHEMBL4550026 | — | — | 1 | - |
| CHEMBL4580470 | — | — | 1 | - |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | - |
| CHEMBL4455126 | — | — | 1 | - |
| CHEMBL4580991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4534306 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4551610 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4539172 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4539586 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4582915 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4546338 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4474060 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL4582915 | — | MIC | = | 88000.0 | nM | - |
| CHEMBL4453865 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4546338 | — | MIC | = | 40000.0 | nM | - |
| CHEMBL4473148 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL4457962 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4593096 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4580991 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL4587484 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4580470 | — | MIC | > | 200000.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | MIC | > | 1500.0 | nM | - |
| CHEMBL4455126 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4551610 | — | MIC | = | 28000.0 | nM | - |
| CHEMBL4539172 | — | MIC | = | 16000.0 | nM | - |
| CHEMBL4539586 | — | MIC | = | 15000.0 | nM | - |
| CHEMBL4534306 | — | MIC | > | 1500.0 | nM | - |
| CHEMBL4550026 | — | MIC | > | 1500.0 | nM | - |