Assay Detail
Binding
CHEMBL4427615
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Inhibition of ALK5 in TGF beta1-stimulated HEK293T cells by SMAD binding element-driven beta lactamase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.39 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467267 | — | — | 1 | 8.04 |
| CHEMBL4470706 | — | — | 1 | 8.02 |
| CHEMBL4452818 | — | — | 1 | 7.78 |
| CHEMBL4555703 | — | — | 1 | 7.75 |
| CHEMBL4443611 | — | — | 1 | 7.75 |
| CHEMBL4437930 | — | — | 1 | 7.70 |
| CHEMBL4447510 | — | — | 1 | 7.70 |
| CHEMBL4483492 | — | — | 1 | 7.65 |
| CHEMBL4446613 | — | — | 1 | 7.60 |
| CHEMBL4576833 | — | — | 1 | 7.30 |
| CHEMBL4470980 | — | — | 1 | 7.29 |
| CHEMBL4572312 | — | — | 1 | 6.80 |
| CHEMBL4564126 | TP-008 | — | 1 | 6.63 |
| CHEMBL4569690 | — | — | 1 | 6.48 |
| CHEMBL4515962 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467267 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL4470706 | — | EC50 | = | 9.55 | nM | 8.02 |
| CHEMBL4452818 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL4555703 | — | EC50 | = | 17.78 | nM | 7.75 |
| CHEMBL4443611 | — | EC50 | = | 17.78 | nM | 7.75 |
| CHEMBL4437930 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4447510 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4483492 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL4446613 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4576833 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4470980 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL4572312 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4564126 | TP-008 | EC50 | = | 234.42 | nM | 6.63 |
| CHEMBL4569690 | — | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL4515962 | — | EC50 | = | 457.09 | nM | 6.34 |