Compound Detail
CHEMBL4467267
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Basic Information
| ChEMBL ID | CHEMBL4467267 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VLGLBSKIKUXFJN-LBPRGKRZSA-N |
1
Targets
2
Activities
2
Assay Types
2
PK Parameters
4
Publications
0
Known Names
Molecular Properties
439.9
MW (Da)
4.27
ALogP
5
HBA
4
HBD
102.9
PSA (Ų)
0.36
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.04
IC50 1 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | EC50 | 8.04 | 8.04 | 9.1 | 1 |
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 7.9 | 7.9 | 12.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 37.0 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 17.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | EC50 | = | 9.12 | nM | 8.04 | Inhibition of ALK5 in TGF beta1-stimulated HEK293T cells by SMAD binding element... | 27460209 |
| TGF-beta receptor type-1 | IC50 | = | 12.59 | nM | 7.9 | Inhibition of ALK5 (unknown origin) using fluorescein-labeled peptide substrate ... | 27460209 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27460209 | 10.1016/j.bmcl.2016.07.030 | TGF-beta receptor type-1 | 2 |
| 27460209 | 10.1016/j.bmcl.2016.07.030 | ADMET | 2 |
| 27460209 | 10.1016/j.bmcl.2016.07.030 | Cytochrome P450 1A2 | 1 |
| 27460209 | 10.1016/j.bmcl.2016.07.030 | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine