Assay Detail

CHEMBL4428176

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Binding

Displacement of bis-ANS from Escherichia coli FtsZ

ChEMBL ↗

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Target

Cell division protein FtsZ (CHEMBL3999) ↗

Open DB target context

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Cell division protein FtsZ (CHEMBL3999) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cell division protein FtsZ

CHEMBL3999

Anchored from Assay target.

Protein identity Cell division protein FtsZ

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Cell division protein FtsZ (CHEMBL3999) ↗

Type	SINGLE PROTEIN
Organism	Escherichia coli K-12

Publication

Targeting the Bacterial Division Protein FtsZ.

Hurley KA, Santos TM, Nepomuceno GM, Huynh V, Shaw JT, Weibel DB.
J Med Chem (2016) 59 : 6975 -6998
PubMed 26756351 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	7.64	7.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL12089	BERBERINE CHLORIDE	1.0	1	7.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL12089	BERBERINE CHLORIDE	Kd	=	23.0	nM	7.64