Assay Detail
Binding
CHEMBL4428225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.32 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451948 | — | — | 1 | 5.83 |
| CHEMBL4475597 | — | — | 1 | 5.63 |
| CHEMBL4458105 | — | — | 1 | 5.38 |
| CHEMBL4442682 | — | — | 1 | 5.38 |
| CHEMBL4521088 | — | — | 1 | 5.33 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.39 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451948 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4475597 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4458105 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL4442682 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL4521088 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL140 | CURCUMIN | IC50 | = | 40560.0 | nM | 4.39 |
| CHEMBL303697 | LIGUSTRAZINE | IC50 | > | 200000.0 | nM | - |