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Assay Detail

CHEMBL4428334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant C-terminal truncated human SPC7 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Proprotein convertase subtilisin/kexin type 7 (CHEMBL2232)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases.
Kumar R, Juillerat-Jeanneret L, Golshayan D.
J Med Chem (2016) 59 : 7719 -7737
PubMed 27045975 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.92 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3126388 1 9.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3126388 Ki = 0.12 nM 9.92