Assay Detail
Functional
CHEMBL4428412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation after 96 hrs by sulforhodamine B assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 5.01 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437235 | — | — | 1 | 5.75 |
| CHEMBL3781042 | — | — | 1 | 5.70 |
| CHEMBL4525193 | — | — | 1 | 5.55 |
| CHEMBL4582427 | — | — | 1 | 5.51 |
| CHEMBL3781066 | — | — | 1 | 5.46 |
| CHEMBL4522434 | — | — | 1 | 5.27 |
| CHEMBL4461685 | — | — | 1 | 5.26 |
| CHEMBL4437507 | — | — | 1 | 5.24 |
| CHEMBL4537937 | — | — | 1 | 5.24 |
| CHEMBL4538238 | — | — | 1 | 5.17 |
| CHEMBL4531265 | — | — | 1 | 5.12 |
| CHEMBL3780432 | — | — | 1 | 5.11 |
| CHEMBL4475149 | — | — | 1 | 5.11 |
| CHEMBL4476703 | — | — | 1 | 5.07 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.99 |
| CHEMBL4531654 | — | — | 1 | 4.93 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.90 |
| CHEMBL4535228 | — | — | 1 | 4.84 |
| CHEMBL4467291 | — | — | 1 | 4.84 |
| CHEMBL4462560 | — | — | 1 | 4.83 |
| CHEMBL3779951 | — | — | 1 | 4.82 |
| CHEMBL4520319 | — | — | 1 | 4.82 |
| CHEMBL4563430 | — | — | 1 | 4.79 |
| CHEMBL508614 | — | — | 1 | 4.78 |
| CHEMBL4458605 | — | — | 1 | 4.78 |
| CHEMBL4444381 | — | — | 1 | 4.78 |
| CHEMBL4530735 | — | — | 1 | 4.75 |
| CHEMBL4467226 | — | — | 1 | 4.71 |
| CHEMBL4558896 | — | — | 1 | 4.63 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437235 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3781042 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4525193 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4582427 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3781066 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4522434 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4461685 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4437507 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4537937 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4538238 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4531265 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3780432 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4475149 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4476703 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL269277 | BETULINIC ACID | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4531654 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL169 | URSOLIC ACID | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4535228 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4467291 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4462560 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3779951 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4520319 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4563430 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL508614 | — | EC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4458605 | — | EC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4444381 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4530735 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4467226 | — | EC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4558896 | — | EC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL201515 | MASLINIC ACID | EC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4450632 | — | EC50 | > | 30000.0 | nM | - |