Assay Detail
Binding
CHEMBL4428693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human adenosine kinase assessed as effect on reduced nicotinamide-adenine dinculeotide appearance using inosine as substrate in presence of NAD, ATP incubated for 4 hrs by IMPDH based coupled enzymatic assay based non-isotopic method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.34 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460859 | — | — | 1 | 7.32 |
| CHEMBL4578381 | — | — | 1 | 7.06 |
| CHEMBL4570382 | — | — | 1 | 6.96 |
| CHEMBL4560021 | — | — | 1 | 6.94 |
| CHEMBL4439949 | — | — | 1 | 6.94 |
| CHEMBL4552895 | — | — | 1 | 6.85 |
| CHEMBL99203 | IODOTUBERCIDIN | — | 1 | 6.09 |
| CHEMBL4571377 | — | — | 1 | 5.65 |
| CHEMBL4472686 | — | — | 1 | 5.48 |
| CHEMBL4525611 | — | — | 1 | 5.27 |
| CHEMBL4519937 | — | — | 1 | 5.22 |
| CHEMBL4458520 | — | — | 1 | - |
| CHEMBL4539530 | — | — | 1 | - |
| CHEMBL4518728 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460859 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4578381 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4570382 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4560021 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4439949 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4552895 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL99203 | IODOTUBERCIDIN | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4571377 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4472686 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4525611 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL4519937 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL4458520 | — | IC50 | - | — | - | |
| CHEMBL4539530 | — | IC50 | - | — | - | |
| CHEMBL4518728 | — | IC50 | - | — | - |