Assay Detail
Binding
CHEMBL4428801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K p110gamma/p101 (unknown origin) using PIP2/ATP as substrate after 1 hr by kinase glo luminescent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5 (CHEMBL3430881) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4555071 | — | — | 1 | 7.10 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.89 |
| CHEMBL4446205 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4555071 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4446205 | — | IC50 | = | 158.0 | nM | 6.80 |