Assay Detail
Functional
CHEMBL4428811
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Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-N87 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.85 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.22 |
| CHEMBL4457773 | — | — | 1 | 6.28 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.18 |
| CHEMBL4460361 | — | — | 2 | 6.11 |
| CHEMBL4455733 | — | — | 1 | 5.92 |
| CHEMBL4442758 | — | — | 1 | 5.89 |
| CHEMBL4446205 | — | — | 2 | 5.87 |
| CHEMBL4540522 | — | — | 1 | 5.85 |
| CHEMBL4457370 | — | — | 1 | 5.71 |
| CHEMBL4453932 | — | — | 1 | 5.56 |
| CHEMBL4555071 | — | — | 1 | 5.38 |
| CHEMBL4528366 | — | — | 1 | 5.33 |
| CHEMBL4463279 | — | — | 1 | 5.21 |
| CHEMBL4548366 | — | — | 1 | - |
| CHEMBL4522487 | — | — | 1 | - |
| CHEMBL4444148 | — | — | 1 | - |
| CHEMBL4575186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4457773 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4460361 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4455733 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4442758 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4446205 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4540522 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4457370 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4453932 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4460361 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4555071 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL4528366 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL4463279 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL4522487 | — | IC50 | - | — | - | |
| CHEMBL4444148 | — | IC50 | - | — | - | |
| CHEMBL4548366 | — | IC50 | - | — | - | |
| CHEMBL4575186 | — | IC50 | - | — | - | |
| CHEMBL4446205 | — | IC50 | - | — | - |