Assay Detail
Functional
CHEMBL4428814
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Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.58 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.10 |
| CHEMBL4457773 | — | — | 1 | 5.70 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 5.68 |
| CHEMBL4540522 | — | — | 1 | 5.57 |
| CHEMBL4446205 | — | — | 1 | 5.33 |
| CHEMBL4457370 | — | — | 1 | 5.32 |
| CHEMBL4455733 | — | — | 1 | 5.26 |
| CHEMBL4463279 | — | — | 1 | 5.25 |
| CHEMBL4460361 | — | — | 1 | 5.00 |
| CHEMBL4444148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4457773 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4540522 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4446205 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4457370 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL4455733 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4463279 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL4460361 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4444148 | — | IC50 | - | — | - |