Assay Detail
Functional
CHEMBL4428819
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Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442758 | — | — | 1 | 6.03 |
| CHEMBL4555071 | — | — | 1 | 5.60 |
| CHEMBL4460361 | — | — | 1 | 5.57 |
| CHEMBL4528366 | — | — | 1 | 5.36 |
| CHEMBL4453932 | — | — | 1 | 5.31 |
| CHEMBL4548366 | — | — | 1 | - |
| CHEMBL4522487 | — | — | 1 | - |
| CHEMBL4575186 | — | — | 1 | - |
| CHEMBL4446205 | — | — | 1 | - |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442758 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4555071 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4460361 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4528366 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL4453932 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4548366 | — | IC50 | - | — | - | |
| CHEMBL4522487 | — | IC50 | - | — | - | |
| CHEMBL4575186 | — | IC50 | - | — | - | |
| CHEMBL4446205 | — | IC50 | - | — | - | |
| CHEMBL99 | TRICHOSTATIN | IC50 | - | — | - |