Assay Detail
Binding
CHEMBL4428871
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Inhibition of factor 10a (unknown origin) using Ac-QRSRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.76 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470708 | — | — | 1 | 6.44 |
| CHEMBL4440685 | — | — | 1 | 6.34 |
| CHEMBL4577000 | — | — | 1 | 6.24 |
| CHEMBL4446504 | — | — | 1 | 4.02 |
| CHEMBL4590811 | — | — | 1 | - |
| CHEMBL4449980 | — | — | 1 | - |
| CHEMBL4483694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470708 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4440685 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL4577000 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL4446504 | — | Ki | = | 96000.0 | nM | 4.02 |
| CHEMBL4590811 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4449980 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4483694 | — | Ki | > | 10000.0 | nM | - |