Assay Detail
Binding
CHEMBL4430163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 cotreated at 72 hrs by MTS assay (Rvb = 6.70 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.71 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457540 | — | — | 1 | 5.97 |
| CHEMBL4470997 | — | — | 1 | 5.61 |
| CHEMBL4441387 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457540 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4470997 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4441387 | — | IC50 | = | 2880.0 | nM | 5.54 |