Assay Detail
Binding
CHEMBL4430453
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Reversible inhibition of recombinant human Adk-short expressed in Escherichia coli BL21[DE3] assessed as [3H]AMP formation preincubated for 15 mins followed by [3H]adenosine addition measured after 30 mins by liquid scintillation counting method
14
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Focused screening to identify new adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.32 | 7.79 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99203 | IODOTUBERCIDIN | — | 2 | 7.79 |
| CHEMBL4570031 | — | — | 1 | 6.74 |
| CHEMBL494210 | — | — | 1 | 5.30 |
| CHEMBL4460819 | — | — | 1 | 5.26 |
| CHEMBL4524434 | — | — | 1 | 5.25 |
| CHEMBL4460655 | — | — | 1 | 5.07 |
| CHEMBL4592393 | — | — | 1 | 5.06 |
| CHEMBL4457103 | — | — | 1 | 5.04 |
| CHEMBL4545415 | — | — | 1 | 4.96 |
| CHEMBL4445820 | — | — | 1 | 4.82 |
| CHEMBL4448716 | — | — | 1 | 4.71 |
| CHEMBL4574016 | — | — | 1 | 4.60 |
| CHEMBL4520524 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99203 | IODOTUBERCIDIN | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL4570031 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL494210 | — | Ki | = | 5040.0 | nM | 5.30 |
| CHEMBL4460819 | — | Ki | = | 5440.0 | nM | 5.26 |
| CHEMBL4524434 | — | Ki | = | 5640.0 | nM | 5.25 |
| CHEMBL4460655 | — | Ki | = | 8560.0 | nM | 5.07 |
| CHEMBL4592393 | — | Ki | = | 8750.0 | nM | 5.06 |
| CHEMBL4457103 | — | Ki | = | 9180.0 | nM | 5.04 |
| CHEMBL4545415 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL4445820 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL4448716 | — | Ki | = | 19500.0 | nM | 4.71 |
| CHEMBL4574016 | — | Ki | = | 25200.0 | nM | 4.60 |
| CHEMBL4520524 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL99203 | IODOTUBERCIDIN | Inhibition | - | % | - |