Assay Detail
Binding
CHEMBL4430528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NOD2 over-expressed in HEK-Blue cells assessed as inhibition of C12-iE-DAP induced NF-kappaB transcriptional activity preincubated for 1 hr followed by addition of C12-iE-DAP measured after 18 hrs by SEAP reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleotide-binding oligomerization domain-containing protein 2 (CHEMBL1293266) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.79 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472193 | — | — | 1 | 5.19 |
| CHEMBL4474194 | — | — | 1 | 5.04 |
| CHEMBL1314048 | — | — | 1 | 4.92 |
| CHEMBL4586513 | — | — | 1 | 4.90 |
| CHEMBL4462798 | — | — | 1 | 4.77 |
| CHEMBL378112 | — | — | 1 | 4.63 |
| CHEMBL4534055 | — | — | 1 | 4.61 |
| CHEMBL1412853 | — | — | 1 | 4.26 |
| CHEMBL4451566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472193 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL4474194 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL1314048 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4586513 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4462798 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL378112 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4534055 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL1412853 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL4451566 | — | IC50 | > | 25000.0 | nM | - |