Assay Detail
Binding
CHEMBL4430738
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Activation of mushroom tyrosinase using L-tyrosine as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 4.83 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475422 | — | — | 1 | 5.89 |
| CHEMBL4440265 | — | — | 1 | 5.77 |
| CHEMBL4465047 | — | — | 1 | 5.60 |
| CHEMBL4464052 | — | — | 1 | 5.52 |
| CHEMBL4470012 | — | — | 1 | 5.25 |
| CHEMBL4522700 | — | — | 1 | 5.19 |
| CHEMBL4545495 | — | — | 1 | 5.09 |
| CHEMBL4469401 | — | — | 1 | 5.02 |
| CHEMBL4463325 | — | — | 1 | 4.94 |
| CHEMBL4460236 | — | — | 1 | 4.92 |
| CHEMBL4581303 | — | — | 1 | 4.90 |
| CHEMBL4462337 | — | — | 1 | 4.84 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 4.83 |
| CHEMBL4473442 | — | — | 1 | 4.77 |
| CHEMBL4559940 | — | — | 1 | 4.68 |
| CHEMBL4466784 | — | — | 1 | 4.67 |
| CHEMBL4453720 | — | — | 1 | 4.62 |
| CHEMBL4462990 | — | — | 1 | 4.62 |
| CHEMBL4567344 | — | — | 1 | 4.59 |
| CHEMBL3409828 | — | — | 1 | 4.59 |
| CHEMBL4548215 | — | — | 1 | 4.54 |
| CHEMBL4468479 | — | — | 1 | 4.51 |
| CHEMBL4446279 | — | — | 1 | 4.45 |
| CHEMBL4592732 | — | — | 1 | 4.43 |
| CHEMBL4594133 | — | — | 1 | 4.33 |
| CHEMBL4469461 | — | — | 1 | 4.25 |
| CHEMBL4522932 | — | — | 1 | 4.18 |
| CHEMBL4471626 | — | — | 1 | 4.11 |
| CHEMBL4542422 | — | — | 1 | - |
| CHEMBL4473153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475422 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4440265 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4465047 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4464052 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4470012 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4522700 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4545495 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4469401 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4463325 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4460236 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4581303 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4462337 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL416 | METHOXSALEN | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4473442 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4559940 | — | EC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4466784 | — | EC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4453720 | — | EC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL4462990 | — | EC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4567344 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3409828 | — | EC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4548215 | — | EC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL4468479 | — | EC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL4446279 | — | EC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL4592732 | — | EC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL4594133 | — | EC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL4469461 | — | EC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL4522932 | — | EC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL4471626 | — | EC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL4542422 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4473153 | — | EC50 | > | 100000.0 | nM | - |