Assay Detail
Functional
CHEMBL4430767
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Antitubercular activity against Mycobacterium tuberculosis H37Ra incubated for 7 days by Alamar blue dye-based fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.93 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 5.69 |
| CHEMBL4525397 | — | — | 1 | 4.87 |
| CHEMBL4524408 | — | — | 1 | 4.71 |
| CHEMBL2375780 | — | — | 1 | 4.69 |
| CHEMBL4565346 | — | — | 1 | 4.68 |
| CHEMBL4469740 | — | — | 1 | - |
| CHEMBL124518 | PHORBOL | — | 1 | - |
| CHEMBL4471846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64 | ISONIAZID | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL4525397 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4524408 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL2375780 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4565346 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4469740 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL124518 | PHORBOL | IC50 | > | 30000.0 | nM | - |
| CHEMBL4471846 | — | IC50 | > | 30000.0 | nM | - |