Assay Detail
Binding
CHEMBL4430769
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Displacement of [3H]U69593 from rat KOR expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.75 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290543 | — | — | 1 | 9.22 |
| CHEMBL3759092 | — | — | 1 | 6.96 |
| CHEMBL4575464 | — | — | 1 | 6.72 |
| CHEMBL4453773 | — | — | 1 | 6.43 |
| CHEMBL4442357 | — | — | 1 | 6.17 |
| CHEMBL4562025 | — | — | 1 | 6.05 |
| CHEMBL4464491 | — | — | 1 | 5.72 |
| CHEMBL4545050 | — | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL38874 | DAMGO | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290543 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3759092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4575464 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4453773 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL4442357 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL4562025 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL4464491 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4545050 | — | Ki | - | — | - | |
| CHEMBL31421 | — | Ki | - | — | - | |
| CHEMBL38874 | DAMGO | Ki | - | — | - |