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Assay Detail

CHEMBL4430794

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ADMET
Antiproliferative activity against HLMEC after 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents.
Ziemska J, Guśpiel A, Jarosz J, Nasulewicz-Goldeman A, Wietrzyk J, Kawęcki R, Pypowski K, Jarończyk M, Solecka J.
Bioorg Med Chem (2016) 24 : 5302 -5314
PubMed 27624521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.75 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4483393 1 5.17
CHEMBL4467841 1 4.33
CHEMBL4537106 1 -
CHEMBL4455383 1 -
CHEMBL4557950 1 -
CHEMBL4576374 1 -
CHEMBL4454667 1 -
CHEMBL4464704 1 -
CHEMBL4456116 1 -
CHEMBL4435767 1 -
CHEMBL4460083 1 -
CHEMBL29292 UBENIMEX 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4483393 IC50 = 6800.0 nM 5.17
CHEMBL4467841 IC50 = 46500.0 nM 4.33
CHEMBL4537106 IC50 = 149600.0 nM -
CHEMBL4455383 IC50 = 1551100.0 nM -
CHEMBL4557950 IC50 = 1362900.0 nM -
CHEMBL4576374 IC50 = 561700.0 nM -
CHEMBL4454667 IC50 = 125800.0 nM -
CHEMBL4464704 IC50 = 307400.0 nM -
CHEMBL4456116 IC50 = 1144500.0 nM -
CHEMBL4435767 IC50 = 657400.0 nM -
CHEMBL4460083 IC50 = 1588100.0 nM -
CHEMBL29292 UBENIMEX IC50 - -