Assay Detail
Binding
CHEMBL4431139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of topoisomerase-1 (unknown origin) using pBR 322 DNA as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.77 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435191 | EDOTECARIN | 3.0 | 1 | 7.29 |
| CHEMBL4558879 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435191 | EDOTECARIN | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4558879 | — | EC50 | = | 580.0 | nM | 6.24 |