Assay Detail
Binding
CHEMBL4431175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptake
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1B1 (CHEMBL1697668) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AZD2716: A Novel Secreted Phospholipase A<sub>2</sub> (sPLA<sub>2</sub>) Inhibitor for the Treatment of Coronary Artery Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457557 | — | — | 1 | 5.70 |
| CHEMBL4533403 | — | — | 1 | - |
| CHEMBL4453126 | — | — | 1 | - |
| CHEMBL4555962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457557 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4533403 | — | IC50 | - | — | - | |
| CHEMBL4453126 | — | IC50 | - | — | - | |
| CHEMBL4555962 | — | IC50 | - | — | - |