Assay Detail
Binding
CHEMBL4431229
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Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.72 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065858 | — | — | 1 | 8.30 |
| CHEMBL4436150 | — | — | 1 | 7.52 |
| CHEMBL4467769 | — | — | 1 | 7.46 |
| CHEMBL4576717 | — | — | 1 | 7.46 |
| CHEMBL4536094 | — | — | 1 | 7.34 |
| CHEMBL4520899 | — | — | 1 | 7.31 |
| CHEMBL4444963 | — | — | 1 | 7.30 |
| CHEMBL4453059 | — | — | 1 | 7.26 |
| CHEMBL4521960 | — | — | 1 | 7.24 |
| CHEMBL4475593 | — | — | 1 | 7.22 |
| CHEMBL4543949 | — | — | 1 | 7.16 |
| CHEMBL4450897 | — | — | 1 | 7.12 |
| CHEMBL4435570 | — | — | 1 | 7.11 |
| CHEMBL4543194 | — | — | 1 | 7.10 |
| CHEMBL4557701 | — | — | 1 | 6.85 |
| CHEMBL4589484 | — | — | 1 | 6.85 |
| CHEMBL4534918 | — | — | 1 | 6.85 |
| CHEMBL4545064 | — | — | 1 | 6.80 |
| CHEMBL4583899 | — | — | 1 | 6.75 |
| CHEMBL4555982 | — | — | 1 | 6.72 |
| CHEMBL4578904 | — | — | 1 | 6.70 |
| CHEMBL4437061 | — | — | 1 | 6.68 |
| CHEMBL4474069 | — | — | 1 | 6.60 |
| CHEMBL4444202 | — | — | 1 | 6.57 |
| CHEMBL4468333 | — | — | 1 | 6.41 |
| CHEMBL4445937 | — | — | 1 | 6.32 |
| CHEMBL4574842 | — | — | 1 | 6.18 |
| CHEMBL4530052 | — | — | 1 | 6.13 |
| CHEMBL4575930 | — | — | 1 | 6.11 |
| CHEMBL4591832 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065858 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4436150 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4576717 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4467769 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4536094 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4520899 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4444963 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4453059 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4521960 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4475593 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4543949 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4450897 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4435570 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4543194 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4534918 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4557701 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4589484 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4545064 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4583899 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4555982 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4578904 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4437061 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4474069 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4444202 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4468333 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4445937 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4574842 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4530052 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4575930 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4591832 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4529408 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4522422 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4566884 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4468343 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3358863 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4458771 | — | IC50 | > | 10000.0 | nM | - |