Assay Detail
Functional
CHEMBL4431271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HEL cells harboring JAK2 V617F mutant after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Antitumor Evaluation of 4-Amino-(1<i>H</i>)-pyrazole Derivatives as JAKs Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.71 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448847 | — | — | 1 | 6.46 |
| CHEMBL4453646 | — | — | 1 | 5.97 |
| CHEMBL4439885 | — | — | 1 | 5.93 |
| CHEMBL4459309 | — | — | 1 | 5.91 |
| CHEMBL4474915 | — | — | 1 | 5.82 |
| CHEMBL4476622 | — | — | 1 | 5.75 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 5.58 |
| CHEMBL4555319 | — | — | 1 | 5.40 |
| CHEMBL4537769 | — | — | 1 | 5.23 |
| CHEMBL4583672 | — | — | 1 | 5.01 |
| CHEMBL4483021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448847 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4453646 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4439885 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL4459309 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4474915 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4476622 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4555319 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4537769 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4583672 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL4483021 | — | IC50 | - | — | - |