Assay Detail

CHEMBL4431775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Endothelin-1 receptor (CHEMBL252) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Endothelin-1 receptor (CHEMBL252) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Endothelin-1 receptor

CHEMBL252

Anchored from Assay target.

Protein identity Endothelin-1 receptor

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	CHO
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Endothelin-1 receptor (CHEMBL252) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis.

Aubert JD, Juillerat-Jeanneret L.
J Med Chem (2016) 59 : 8168 -8188
PubMed 27266371 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.47	10.47
IC50	1	10.26	10.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL9194	ATRASENTAN	3.0	2	10.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL9194	ATRASENTAN	Ki	=	0.034	nM	10.47
CHEMBL9194	ATRASENTAN	IC50	=	0.055	nM	10.26