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Assay Detail

CHEMBL4431871

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.
Wang T, Mäser P, Picard D.
J Med Chem (2016) 59 : 6344 -6352
PubMed 27312008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.16 6.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3359320 1 6.01
CHEMBL598685 1 5.58
CHEMBL580701 1 5.48
CHEMBL546162 1 5.44
CHEMBL1476463 1 5.44
CHEMBL585793 1 5.44
CHEMBL601604 1 5.43
CHEMBL4544670 1 5.21
CHEMBL4518197 1 5.16
CHEMBL4522703 1 5.14
CHEMBL4465893 1 5.13
CHEMBL4548520 1 5.01
CHEMBL4446324 1 5.01
CHEMBL4473965 1 4.99
CHEMBL589703 1 4.97
CHEMBL584715 1 4.94
CHEMBL4587756 1 4.60
CHEMBL4517797 1 4.58
CHEMBL1336576 1 4.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3359320 IC50 = 975.0 nM 6.01
CHEMBL598685 IC50 = 2613.0 nM 5.58
CHEMBL580701 IC50 = 3339.0 nM 5.48
CHEMBL546162 IC50 = 3668.0 nM 5.44
CHEMBL1476463 IC50 = 3657.0 nM 5.44
CHEMBL585793 IC50 = 3599.0 nM 5.44
CHEMBL601604 IC50 = 3673.0 nM 5.43
CHEMBL4544670 IC50 = 6219.0 nM 5.21
CHEMBL4518197 IC50 = 6853.0 nM 5.16
CHEMBL4522703 IC50 = 7211.0 nM 5.14
CHEMBL4465893 IC50 = 7375.0 nM 5.13
CHEMBL4548520 IC50 = 9723.0 nM 5.01
CHEMBL4446324 IC50 = 9723.0 nM 5.01
CHEMBL4473965 IC50 = 10210.0 nM 4.99
CHEMBL589703 IC50 = 10786.0 nM 4.97
CHEMBL584715 IC50 = 11585.0 nM 4.94
CHEMBL4587756 IC50 = 25155.0 nM 4.60
CHEMBL4517797 IC50 = 26483.0 nM 4.58
CHEMBL1336576 IC50 = 37666.0 nM 4.42