Assay Detail
Functional
CHEMBL4431952
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Cytotoxicity against human HCT116 cells by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.52 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4591736 | — | — | 1 | 5.13 |
| CHEMBL4448508 | — | — | 1 | 4.57 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 4.19 |
| CHEMBL4530032 | — | — | 1 | 4.18 |
| CHEMBL4447698 | — | — | 1 | - |
| CHEMBL4448791 | — | — | 1 | - |
| CHEMBL4472182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4591736 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4448508 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL4530032 | — | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL4447698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4448791 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4472182 | — | IC50 | > | 100000.0 | nM | - |