Assay Detail

CHEMBL4432033

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Functional

Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms compound treated through encapsulation in PLGA nanoparticles after 72 hrs by resazurin-based assay

ChEMBL ↗

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Target

Trypanosoma brucei brucei (CHEMBL612851) ↗

Open DB target context

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Trypanosoma brucei brucei (CHEMBL612851) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei brucei

CHEMBL612851

Anchored from Assay target.

Protein identity Trypanosoma brucei brucei

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei brucei
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851) ↗

Type	ORGANISM
Organism	Trypanosoma brucei brucei

Publication

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.
J Med Chem (2016) 59 : 7598 -7616
PubMed 27411733 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.24	5.24

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4464764	—	—	1	5.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4464764	—	EC50	=	5700.0	nM	5.24