Assay Detail
Binding
CHEMBL4432063
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Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibitory effects of new N-glycosylsulfonamides incorporating the phenol moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.70 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454282 | — | — | 1 | 7.37 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4465817 | — | — | 1 | 6.34 |
| CHEMBL4458516 | — | — | 1 | 5.42 |
| CHEMBL4443182 | — | — | 1 | 5.39 |
| CHEMBL224292 | — | — | 1 | 5.26 |
| CHEMBL4565694 | — | — | 1 | 5.20 |
| CHEMBL4459557 | — | — | 1 | 5.18 |
| CHEMBL4469108 | — | — | 1 | 5.17 |
| CHEMBL4449836 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454282 | — | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4465817 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL4458516 | — | Ki | = | 3840.0 | nM | 5.42 |
| CHEMBL4443182 | — | Ki | = | 4025.0 | nM | 5.39 |
| CHEMBL224292 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL4565694 | — | Ki | = | 6250.0 | nM | 5.20 |
| CHEMBL4459557 | — | Ki | = | 6630.0 | nM | 5.18 |
| CHEMBL4469108 | — | Ki | = | 6690.0 | nM | 5.17 |
| CHEMBL4449836 | — | Ki | = | 8850.0 | nM | 5.05 |