Assay Detail
Functional
CHEMBL4432236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CB2R expressed in CHO cells by Ca2+ flux assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.72 | 7.03 |
| Emax | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443660 | — | — | 2 | 7.03 |
| CHEMBL127644 | — | — | 2 | 6.86 |
| CHEMBL4483714 | — | — | 2 | 6.79 |
| CHEMBL123515 | — | — | 2 | 6.71 |
| CHEMBL4550629 | — | — | 2 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443660 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL127644 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL4483714 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL123515 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4550629 | — | EC50 | = | 594.0 | nM | 6.23 |
| CHEMBL127644 | — | Emax | = | 27.0 | % | - |
| CHEMBL123515 | — | Emax | = | 52.0 | % | - |
| CHEMBL4550629 | — | Emax | = | 20.0 | % | - |
| CHEMBL4483714 | — | Emax | = | 59.0 | % | - |
| CHEMBL4443660 | — | Emax | = | 69.0 | % | - |