Assay Detail
Binding
CHEMBL4432244
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Inhibition of Helicobacter pylori urease using urea as substrate assessed as ammonia production after 50 mins by indophenol method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.48 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590676 | — | — | 1 | 6.82 |
| CHEMBL2425480 | — | — | 1 | 5.96 |
| CHEMBL4545901 | — | — | 1 | 4.87 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.62 |
| CHEMBL4568283 | — | — | 1 | 4.58 |
| CHEMBL4469655 | — | — | 1 | 4.52 |
| CHEMBL4516908 | — | — | 1 | 4.32 |
| CHEMBL4555761 | — | — | 1 | 4.25 |
| CHEMBL4585313 | — | — | 1 | 4.15 |
| CHEMBL4579243 | — | — | 1 | 4.11 |
| CHEMBL4470787 | — | — | 1 | 4.11 |
| CHEMBL4439781 | — | — | 1 | 4.11 |
| CHEMBL4539763 | — | — | 1 | 4.08 |
| CHEMBL4473012 | — | — | 1 | 4.06 |
| CHEMBL4535418 | — | — | 1 | 4.05 |
| CHEMBL4530689 | — | — | 1 | 4.04 |
| CHEMBL4440368 | — | — | 1 | 4.02 |
| CHEMBL4461397 | — | — | 1 | 4.01 |
| CHEMBL4454777 | — | — | 1 | - |
| CHEMBL4437504 | — | — | 1 | - |
| CHEMBL4534392 | — | — | 1 | - |
| CHEMBL4476469 | — | — | 1 | - |
| CHEMBL4472402 | — | — | 1 | - |
| CHEMBL4531553 | — | — | 1 | - |
| CHEMBL4447735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590676 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2425480 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4545901 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL4568283 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4469655 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL4516908 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4555761 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL4585313 | — | IC50 | = | 71200.0 | nM | 4.15 |
| CHEMBL4579243 | — | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL4470787 | — | IC50 | = | 78200.0 | nM | 4.11 |
| CHEMBL4439781 | — | IC50 | = | 77200.0 | nM | 4.11 |
| CHEMBL4539763 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4473012 | — | IC50 | = | 87400.0 | nM | 4.06 |
| CHEMBL4535418 | — | IC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL4530689 | — | IC50 | = | 90400.0 | nM | 4.04 |
| CHEMBL4440368 | — | IC50 | = | 95800.0 | nM | 4.02 |
| CHEMBL4461397 | — | IC50 | = | 97600.0 | nM | 4.01 |
| CHEMBL4454777 | — | IC50 | = | 328000.0 | nM | - |
| CHEMBL4437504 | — | IC50 | = | 287000.0 | nM | - |
| CHEMBL4534392 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL4476469 | — | IC50 | = | 258000.0 | nM | - |
| CHEMBL4472402 | — | IC50 | = | 367000.0 | nM | - |
| CHEMBL4531553 | — | IC50 | = | 376000.0 | nM | - |
| CHEMBL4447735 | — | IC50 | = | 405000.0 | nM | - |