Assay Detail
Binding
CHEMBL4432475
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Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.43 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443952 | — | — | 1 | 9.22 |
| CHEMBL4578460 | — | — | 1 | 9.15 |
| CHEMBL4539641 | — | — | 1 | 9.00 |
| CHEMBL4476854 | — | — | 1 | 8.77 |
| CHEMBL4552325 | — | — | 1 | 8.77 |
| CHEMBL4582423 | — | — | 1 | 8.74 |
| CHEMBL4437901 | — | — | 1 | 8.68 |
| CHEMBL4467949 | — | — | 1 | 8.64 |
| CHEMBL4461741 | — | — | 1 | 8.62 |
| CHEMBL4458142 | — | — | 1 | 8.62 |
| CHEMBL4468577 | — | — | 1 | 8.60 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.59 |
| CHEMBL4473908 | — | — | 1 | 8.41 |
| CHEMBL4589258 | — | — | 1 | 8.38 |
| CHEMBL4455924 | — | — | 1 | 8.33 |
| CHEMBL4528003 | — | — | 1 | 8.33 |
| CHEMBL4583172 | — | — | 1 | 8.19 |
| CHEMBL4542515 | — | — | 1 | 8.03 |
| CHEMBL4571149 | — | — | 1 | 8.01 |
| CHEMBL4527370 | — | — | 1 | 6.98 |
| CHEMBL4461009 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443952 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4578460 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4539641 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4476854 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4552325 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4582423 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4437901 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4467949 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4461741 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4458142 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4468577 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4473908 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4589258 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4455924 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4528003 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4583172 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4542515 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4571149 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4527370 | — | IC50 | = | 104.9 | nM | 6.98 |
| CHEMBL4461009 | — | IC50 | = | 132.7 | nM | 6.88 |