Assay Detail
Binding
CHEMBL4432495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-Met (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.40 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 8.41 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.96 |
| CHEMBL4514997 | — | — | 1 | 7.85 |
| CHEMBL3989914 | GLESATINIB | 2.0 | 1 | 7.54 |
| CHEMBL404881 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4514997 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3989914 | GLESATINIB | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL404881 | — | IC50 | = | 80.0 | nM | 7.10 |