Assay Detail
Binding
CHEMBL4432503
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Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 after 120 mins by Berthelot colorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.86 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4575318 | — | — | 1 | 6.74 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.65 |
| CHEMBL385817 | EBSELEN DISELENIDE | — | 1 | 6.19 |
| CHEMBL4471428 | — | — | 1 | 6.04 |
| CHEMBL4539240 | — | — | 1 | 5.49 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4575318 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL51085 | EBSELEN | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL385817 | EBSELEN DISELENIDE | Ki | = | 651.0 | nM | 6.19 |
| CHEMBL4471428 | — | Ki | = | 915.0 | nM | 6.04 |
| CHEMBL4539240 | — | Ki | = | 3259.0 | nM | 5.49 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | Ki | = | 96000.0 | nM | 4.02 |