Assay Detail
Binding
CHEMBL4432504
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Inhibition of recombinant Helicobacter pylori urease expressed in Escherichia coli rosetta DE3 using urea as substrate assessed as transformed cell urea splitting activity after 2 hrs by Berthelot assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.12 | 4.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655716 | — | — | 1 | 4.31 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 4.16 |
| CHEMBL4563587 | — | — | 1 | 4.12 |
| CHEMBL4469439 | — | — | 1 | 4.10 |
| CHEMBL3747132 | — | — | 1 | 4.07 |
| CHEMBL385817 | EBSELEN DISELENIDE | — | 1 | 4.06 |
| CHEMBL4563580 | — | — | 1 | 4.02 |
| CHEMBL4552531 | — | — | 1 | - |
| CHEMBL4444989 | — | — | 1 | - |
| CHEMBL4089739 | — | — | 1 | - |
| CHEMBL4463967 | — | — | 1 | - |
| CHEMBL4592440 | — | — | 1 | - |
| CHEMBL4444060 | — | — | 1 | - |
| CHEMBL4469463 | — | — | 1 | - |
| CHEMBL4534596 | — | — | 1 | - |
| CHEMBL4520558 | — | — | 1 | - |
| CHEMBL3747547 | — | — | 1 | - |
| CHEMBL4524305 | — | — | 1 | - |
| CHEMBL4461450 | — | — | 1 | - |
| CHEMBL4471428 | — | — | 1 | - |
| CHEMBL4575318 | — | — | 1 | - |
| CHEMBL1976884 | — | — | 1 | - |
| CHEMBL4555455 | — | — | 1 | - |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
| CHEMBL4539240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655716 | — | IC50 | = | 48600.0 | nM | 4.31 |
| CHEMBL51085 | EBSELEN | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4563587 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4469439 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3747132 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL385817 | EBSELEN DISELENIDE | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4563580 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL4552531 | — | IC50 | - | — | - | |
| CHEMBL4444989 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL4089739 | — | IC50 | = | 107700.0 | nM | - |
| CHEMBL4463967 | — | IC50 | = | 301000.0 | nM | - |
| CHEMBL4592440 | — | IC50 | = | 186000.0 | nM | - |
| CHEMBL4444060 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL4469463 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL4534596 | — | IC50 | - | — | - | |
| CHEMBL4520558 | — | IC50 | = | 388000.0 | nM | - |
| CHEMBL3747547 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL4524305 | — | IC50 | - | — | - | |
| CHEMBL4461450 | — | IC50 | - | — | - | |
| CHEMBL4471428 | — | IC50 | - | — | - | |
| CHEMBL4575318 | — | IC50 | - | — | - | |
| CHEMBL1976884 | — | IC50 | - | — | - | |
| CHEMBL4555455 | — | IC50 | - | — | - | |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 154000.0 | nM | - |
| CHEMBL4539240 | — | IC50 | - | — | - |