Assay Detail
Binding
CHEMBL4432507
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Inhibition of urease in Helicobacter pylori J99 in Brucella broth using urea as substrate preincubated for 2 hrs followed by substrate addition measured after 2 hrs by Berthelot assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori J99 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.99 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089739 | — | — | 1 | 5.67 |
| CHEMBL4469463 | — | — | 1 | 5.50 |
| CHEMBL4444060 | — | — | 1 | 5.48 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.43 |
| CHEMBL4563587 | — | — | 1 | 5.41 |
| CHEMBL4563580 | — | — | 1 | 5.39 |
| CHEMBL4524305 | — | — | 1 | 5.30 |
| CHEMBL4469439 | — | — | 1 | 5.30 |
| CHEMBL385817 | EBSELEN DISELENIDE | — | 1 | 5.17 |
| CHEMBL3655716 | — | — | 1 | 5.16 |
| CHEMBL4575318 | — | — | 1 | 4.93 |
| CHEMBL4592440 | — | — | 1 | 4.59 |
| CHEMBL4520558 | — | — | 1 | 4.29 |
| CHEMBL4463967 | — | — | 1 | 4.16 |
| CHEMBL4471428 | — | — | 1 | 4.08 |
| CHEMBL4444989 | — | — | 1 | 4.01 |
| CHEMBL4534596 | — | — | 1 | - |
| CHEMBL4552531 | — | — | 1 | - |
| CHEMBL4539240 | — | — | 1 | - |
| CHEMBL3747547 | — | — | 1 | - |
| CHEMBL3747132 | — | — | 1 | - |
| CHEMBL4461450 | — | — | 1 | - |
| CHEMBL1976884 | — | — | 1 | - |
| CHEMBL4555455 | — | — | 1 | - |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089739 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4469463 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4444060 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL51085 | EBSELEN | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL4563587 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL4563580 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4524305 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL4469439 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL385817 | EBSELEN DISELENIDE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3655716 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL4575318 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4592440 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4520558 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL4463967 | — | IC50 | = | 69500.0 | nM | 4.16 |
| CHEMBL4471428 | — | IC50 | = | 83500.0 | nM | 4.08 |
| CHEMBL4444989 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL4534596 | — | IC50 | = | 611000.0 | nM | - |
| CHEMBL4552531 | — | IC50 | - | — | - | |
| CHEMBL4539240 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3747547 | — | IC50 | = | 357900.0 | nM | - |
| CHEMBL3747132 | — | IC50 | = | 182600.0 | nM | - |
| CHEMBL4461450 | — | IC50 | = | 421000.0 | nM | - |
| CHEMBL1976884 | — | IC50 | - | — | - | |
| CHEMBL4555455 | — | IC50 | - | — | - | |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 156000.0 | nM | - |