Assay Detail
Binding
CHEMBL4433008
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Inhibition of mouse MAO-B preincubated for 15 mins followed by addition of kynuramine as substrate measured after 30 mins by fluorometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453259 | — | — | 1 | 6.10 |
| CHEMBL242341 | FORMONONETIN | 2.0 | 1 | 4.96 |
| CHEMBL307341 | AURAPTENE | — | 1 | - |
| CHEMBL2346911 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453259 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL242341 | FORMONONETIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL307341 | AURAPTENE | IC50 | = | 600.0 | nM | - |
| CHEMBL2346911 | — | IC50 | = | 500.0 | nM | - |